In salutation you can write Sir/Madam
and sirs being plural is never used in letters. Even if you address your letter to more than a single person, you still wrote your salutation as Sir/Madam.
To
1. Alan
2.Desy
Sir/Madam,
In a formal letter the word dear is almost never used. The use of word dear represents your inexperience with writing formal letters.
In informal letters we do not use the word Sir itself. We usually write the name of the person to whom we're writing the letter as the informal letter is meant for the people we know closely.
For example, Dear Nancy (Nancy can be a friend's name or a family members name or name of someone you know closely.)
As an informal letter is written to someone we do not know personally ( usually for official purposes) so the person or persons should be addressed informally at all points in the letter.
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